Synthesis of novel spirooxindoles in water by using MnFe sub(2)O sub(4) nanoparticles as an efficient magnetically recoverable and reusable catalyst

An efficient, clean, atom-economical and simple method for the one-pot synthesis of novel spirooxindole derivatives via a three-component reaction of isatins, dimedone and anilinolactones was reported. This reaction was performed by using MnFe sub(2)O sub(4) nanoparticles (5 mol%) as an efficient magnetically heterogeneous catalyst in water as green solvent. Prominent among the advantages of this method is the use of magnetically recoverable and reusable catalyst, simple work up procedure, good to high product yields and use of water as a solvent that is considered to be relatively environmentally benign.