Electrochemical detection of leukemia oncogenes using enzyme-loaded carbon nanotube labels

We describe an ultrasensitive electrochemical nucleic acid assay amplified by carbon nanotubes (CNTs)-based labels for the detection of human acute lymphocytic leukemia (ALL)-related p185 BCR-ABL fusion transcript. The carboxylated CNTs were functionalized with horseradish peroxidase (HRP) molecules...

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Veröffentlicht in:	Analyst (London) 2014-09, Vol.139 (17), p.4223-4230
Hauptverfasser:	Lee, Ai-Cheng, Du, Dan, Chen, Baowei, Heng, Chew-Kiat, Lim, Tit-Meng, Lin, Yuehe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Assaying Base Sequence Biosensing Techniques Biotechnology Carbon nanotubes Cell Line, Tumor Devices Electrochemical Techniques Environmental Molecular Sciences Laboratory Enzymes, Immobilized - metabolism Fusion Proteins, bcr-abl - genetics Horseradish Peroxidase - metabolism Humans Labels Leukemias Nanotubes, Carbon - chemistry Nucleic Acid Hybridization Nucleic acids Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics RNA, Messenger - analysis RNA, Messenger - genetics
Online-Zugang:	Volltext
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