A Pillararene-Based Ternary Drug-Delivery System with Photocontrolled Anticancer Drug Release

A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py‐Cbl), a water‐soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy‐poly(ethylene glycol)114‐block‐poly(L‐lysine hydrochloride)200. This DDS successfully addresses...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-02, Vol.11 (8), p.919-925
Hauptverfasser:	Yu, Guocan, Yu, Wei, Mao, Zhengwei, Gao, Changyou, Huang, Feihe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Cell Line, Tumor - drug effects Chemical compounds Chlorambucil - chemistry Construction Containers Controlled release Copolymers Drug Carriers - chemistry drug delivery Drug Delivery Systems Drugs host-guest systems Humans Lysine - chemistry Magnetic Resonance Spectroscopy Micelles Nanocapsules - therapeutic use Nanotechnology Neoplasms - pathology Photochemistry pillararenes Prodrugs - chemistry Quaternary Ammonium Compounds - chemistry Reproducibility of Results Solubility supramolecular chemistry Water - chemistry
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Beschreibung
Zusammenfassung:	A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py‐Cbl), a water‐soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy‐poly(ethylene glycol)114‐block‐poly(L‐lysine hydrochloride)200. This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201402236