In-Situ Formation of Growth-Factor-Loaded Coacervate Microparticle-Embedded Hydrogels for Directing Encapsulated Stem Cell Fate

In-Situ Formation of Growth-Factor-Loaded Coacervate Microparticle-Embedded Hydrogels for Directing Encapsulated Stem Cell Fate

The spontaneous formation of coacervate microdroplet‐laden photo‐crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug‐laden microdroplets and encapsulation of stem cells in photopolymeri...

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Veröffentlicht in:Advanced materials (Weinheim) 2015-04, Vol.27 (13), p.2216-2223
Hauptverfasser: Jeon, Oju, Wolfson, David W., Alsberg, Eben
Format: Artikel
Sprache:eng
Schlagworte:
alginate
Alginates
Biocompatibility
Capsules
coacervate
Encapsulation
Formations
gelatin
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
microdroplet
microencapsulation
Microspheres
Platforms
Spontaneous
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Tissue Engineering
Tissue Scaffolds - chemistry
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Zusammenfassung:The spontaneous formation of coacervate microdroplet‐laden photo‐crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug‐laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201405337