Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

Amphiphilic PNIPAM- b -PTPPC6MA block copolymers were first synthesized using porphyrin-containing monomers. The mono-hydroxylphenyl-triphenylporphyrin photosensitizer, TPP-OH, was modified into a porphyrin monomer, and it was further used to construct the amphiphilic PNIPAM- b -PTPPC6MA block copol...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Polymer chemistry 2015-01, Vol.6 (15), p.2945-2954
Hauptverfasser: Xu, Lei, Liu, Lichao, Liu, Feng, Cai, Haibo, Zhang, Weian
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Amphiphilic PNIPAM- b -PTPPC6MA block copolymers were first synthesized using porphyrin-containing monomers. The mono-hydroxylphenyl-triphenylporphyrin photosensitizer, TPP-OH, was modified into a porphyrin monomer, and it was further used to construct the amphiphilic PNIPAM- b -PTPPC6MA block copolymers using RAFT polymerization. PNIPAM- b -PTPPC6MA block copolymers can self-assemble into a plethora of morphologies ranging from spheres to vesicular aggregates and further to a single large vesicle. The PNIPAM- b -PTPPC6MA micelles exhibited a high singlet oxygen quantum yield. Moreover, confocal laser scanning microscopy (CLSM) and flow cytometry analysis confirmed that PNIPAM- b -PTPPC6MA micelles could effectively enhance the internalization rate in MCF-7 cells. According to the MTT assay, PNIPAM- b -PTPPC6MA micelles exhibited low dark toxicity and efficient PDT efficacy towards MCF-7 cells. Thus PNIPAM- b -PTPPC6MA block copolymers have the potential application for photodynamic therapy.
ISSN:1759-9954
1759-9962
DOI:10.1039/C5PY00039D