Effects of Fabrication Errors on the Sensitivity of Nano-Replicated Guided Mode Resonance Protein Sensors

Although an injection molding is a promising method for inexpensive mass production of nanograting substrate for disposable guided mode resonance (GMR) protein sensor, the incomplete filling of nanocavities due to the thick solidified layer in conventional injection molding process may lower the sensitivity of label-free GMR protein sensor. In this study, an instant heating method at the filling stage during the injection molding process was investigated to improve the pattern transcribability of molded nanograting and the sensitivity of fabricated GMR protein sensor. Two types of injection molded nanograting with and without instant heating method were prepared and the effects of pattern fidelity on the performance of fabricated GMR protein sensor were analyzed by theoretical and experimental methods.