Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats

Persistent hyperglycemia and elevated levels of free fatty acids (FFA) contribute to oxidative stress, a proximate cause for the onset and progression of diabetes and its complications. The present study was hypothesized to evaluate the anti-diabetic potential of Rosmarinic acid (RA) during high-fat...

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Veröffentlicht in:	Molecular and cellular biochemistry 2015-06, Vol.404 (1-2), p.143-159
Hauptverfasser:	Govindaraj, Jayanthy, Sorimuthu Pillai, Subramanian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antioxidants Antioxidants - administration & dosage Biochemistry Biomedical and Life Sciences Blood Glucose Blood sugar Carbonyl compounds Cardiology Cinnamates - administration & dosage Complications and side effects Depsides - administration & dosage Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diet Diet, High-Fat Drug therapy Fatty acids Glutathione transferase Glycated Hemoglobin - metabolism Glycation End Products, Advanced - blood Humans Hyperglycemia Insulin Insulin - blood Insulin Resistance - genetics Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - pathology Life Sciences Medical Biochemistry Oils & fats Oncology Oxidative stress Oxidative Stress - drug effects Pancreas - drug effects Pancreas - metabolism Pancreatic beta cells Pancreatic cancer Rats Rodents Rosmarinic Acid Streptozocin Superoxide Tissues Toxicity
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Zusammenfassung:	Persistent hyperglycemia and elevated levels of free fatty acids (FFA) contribute to oxidative stress, a proximate cause for the onset and progression of diabetes and its complications. The present study was hypothesized to evaluate the anti-diabetic potential of Rosmarinic acid (RA) during high-fat diet (HFD)—streptozotocin (STZ)-induced type 2 Diabetes (T2D) in wistar albino rats. Oral administration of RA (100 mg/kg b.w) significantly ( p
ISSN:	0300-8177 1573-4919
DOI:	10.1007/s11010-015-2374-6