Antibacterial Triterpenoids from the Bark of Sonneratia alba (Lythraceae)

Antibacterial Triterpenoids from the Bark of Sonneratia alba (Lythraceae)

The new lupane-type triterpenoid, 3β-hydroxy-lup-9(11), 12-diene, 28-oic acid (1), along with two known lupane-type triterpenoids, lupeol (2) and lupan-3p-ol (3), were isolated from the bark of Sonnetaria alba. The structure of the new compound was elucidated on the basis of spectroscopic and mass s...

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Veröffentlicht in:Natural product communications 2015-02, Vol.10 (2), p.277-280
Hauptverfasser: Harizon, Pujiastuti, Betry, Kurnia, Dikdik, Sumiarsa, Dadan, Shiono, Yoshihito, Supratman, Unang
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Lythraceae - chemistry
Microbial Sensitivity Tests
Molecular Structure
Plant Bark - chemistry
Staphylococcus - drug effects
Triterpenes - chemistry
Triterpenes - pharmacology
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Zusammenfassung:The new lupane-type triterpenoid, 3β-hydroxy-lup-9(11), 12-diene, 28-oic acid (1), along with two known lupane-type triterpenoids, lupeol (2) and lupan-3p-ol (3), were isolated from the bark of Sonnetaria alba. The structure of the new compound was elucidated on the basis of spectroscopic and mass spectrometric data analysis. Using the broth microdilution method, all compounds exhibited antibacterial activity against the Gram-positive bacteria Staphylococcus aureus ATCC 6538 and Streptococcus mutans ATCC 25175, with minimum inhibitory concentrations ranging from 15-33 to 35-55 ng/mL, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1501000215