Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum

Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of prote...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1994-11, Vol.57 (11), p.1543-1548
Hauptverfasser:	Chan, J A, Freyer, A J, Carté, B K, Hemling, M E, Hofmann, G A, Mattern, M R, Mentzer, M A, Westley, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cercopithecus aethiops Humans Magnetic Resonance Spectroscopy Marine Mass Spectrometry Models, Molecular Molecular Conformation Molecular Structure Porifera Protein Kinase C - antagonists & inhibitors Recombinant Proteins - antagonists & inhibitors Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Structure-Activity Relationship Vero Cells
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Beschreibung
Zusammenfassung:	Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of protein kinase C.
ISSN:	0163-3864
DOI:	10.1021/np50113a011