Propofol-ketamine or propofol-remifentanil for deep sedation and analgesia in pediatric patients undergoing burn dressing changes: a randomized clinical trial

Summary Objective In this study, we compared the propofol–ketamine and propofol–remifentanil combinations for deep sedation and analgesia during pediatric burn wound dressing changes. Methods Fifty pediatric patients aged 12–36 months, undergoing burn wound dressing changes, were randomly assigned to receive propofol–remifentanil (group PR) or propofol–ketamine (group PK) for deep sedation and analgesia. Patients in the group PR received 2 mg·kg−1 propofol and 0.1 μg·kg−1 remifentanil, and 0.05 μg·kg−1·min−1 remifentanil was infused continuously until the end of the procedure. Patients in the group PK received 2 mg·kg−1 propofol and 1 mg·kg−1 ketamine, and the same volume of isotonic saline was infused continuously until the end of the procedure. Additional propofol with remifentanil or ketamine was administered when required. Hemodynamic variables, drug requirements, occurrence of patient movement, surgeon's satisfaction score, recovery time, and the incidence of adverse events were recorded throughout the procedure and recovery. Results Recovery time was significantly shorter in the group PR compared to that in the group PK (10.3 [9.1–11.5] min vs 22.5 [20.3–25.6] min, median [interquartile range], respectively; P