Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps
Objectives/Hypothesis To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). Study Design Case series, retrospective study. Methods Patients (n = 18) with sever...
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| Veröffentlicht in: | The Laryngoscope 2015-05, Vol.125 (5), p.E158-E167 |
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| container_title | The Laryngoscope |
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| creator | de Borja Callejas, Francisco Martínez-Antón, Asunción Picado, César Alobid, Isam Pujols, Laura Valero, Antonio Roca-Ferrer, Jordi Mullol, Joaquim |
| description | Objectives/Hypothesis
To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP).
Study Design
Case series, retrospective study.
Methods
Patients (n = 18) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP‐1), MMP‐2, MMP‐7, MMP‐9, and tissue inhibitor of metalloprotease type 1 (TIMP‐1) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment.
Results
Compared to w0: 1) oral plus intranasal CS significantly (P |
| doi_str_mv | 10.1002/lary.25147 |
| format | Article |
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To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP).
Study Design
Case series, retrospective study.
Methods
Patients (n = 18) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP‐1), MMP‐2, MMP‐7, MMP‐9, and tissue inhibitor of metalloprotease type 1 (TIMP‐1) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment.
Results
Compared to w0: 1) oral plus intranasal CS significantly (P < .01) increased presence of submucosal glands at w2, decreased epithelial cell hyperplasia at w12, and decreased tissue eosinophilia at w2 and w12; 2) CS treatment significantly (P < .05) increased immunoreactivity for MMP‐1 and MMP‐2 in the epithelium at w2, but decreased immunoreactivity for MMP‐9 in the epithelium at w2 and w12; 3) at w12, CS significantly (P < .05) reduced MMP‐9 immunoreactive positivity and intensity in the extracellular matrix, while increasing total collagen amount in the extracellular matrix; and 4) CS treatment significantly (P < .01) reduced the number of eosinophils and their MMP and TIMP‐1 immunoreactive expression.
Conclusions
CS treatment modulates NP mucosa remodeling, particularly by promoting epithelial repair, regulating tissue remodeling markers, increasing total collagen content, and reducing tissue eosinophil infiltration.
Level of Evidence
4 Laryngoscope, 125:E158–E167, 2015</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.25147</identifier><identifier>PMID: 25641502</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Administration, Intranasal ; Administration, Oral ; Biopsy ; Budesonide - administration & dosage ; Chronic Disease ; chronic rhinosinusitis with nasal polyp ; Collagen ; Collagenases - biosynthesis ; Corticosteroids ; Drug Therapy, Combination ; eosinophilic inflammation ; Eosinophils - pathology ; Extracellular matrix ; Female ; Glucocorticoids - administration & dosage ; Humans ; Immunohistochemistry ; Male ; matrix metalloproteases ; Middle Aged ; Nasal Mucosa - enzymology ; Nasal Mucosa - pathology ; Nasal Polyps - complications ; Nasal Polyps - drug therapy ; Nasal Polyps - pathology ; Prednisone - administration & dosage ; remodeling ; Retrospective Studies ; Rhinitis - complications ; Rhinitis - drug therapy ; Rhinitis - pathology ; Sinusitis - complications ; Sinusitis - drug therapy ; Sinusitis - pathology ; Tissue Inhibitor of Metalloproteinases - biosynthesis</subject><ispartof>The Laryngoscope, 2015-05, Vol.125 (5), p.E158-E167</ispartof><rights>2015 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4657-a433813da34562b8e4d3dad7ed62658e1cd194f86acebaaea72d2641348053743</citedby><cites>FETCH-LOGICAL-c4657-a433813da34562b8e4d3dad7ed62658e1cd194f86acebaaea72d2641348053743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.25147$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.25147$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25641502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Borja Callejas, Francisco</creatorcontrib><creatorcontrib>Martínez-Antón, Asunción</creatorcontrib><creatorcontrib>Picado, César</creatorcontrib><creatorcontrib>Alobid, Isam</creatorcontrib><creatorcontrib>Pujols, Laura</creatorcontrib><creatorcontrib>Valero, Antonio</creatorcontrib><creatorcontrib>Roca-Ferrer, Jordi</creatorcontrib><creatorcontrib>Mullol, Joaquim</creatorcontrib><title>Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP).
Study Design
Case series, retrospective study.
Methods
Patients (n = 18) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP‐1), MMP‐2, MMP‐7, MMP‐9, and tissue inhibitor of metalloprotease type 1 (TIMP‐1) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment.
Results
Compared to w0: 1) oral plus intranasal CS significantly (P < .01) increased presence of submucosal glands at w2, decreased epithelial cell hyperplasia at w12, and decreased tissue eosinophilia at w2 and w12; 2) CS treatment significantly (P < .05) increased immunoreactivity for MMP‐1 and MMP‐2 in the epithelium at w2, but decreased immunoreactivity for MMP‐9 in the epithelium at w2 and w12; 3) at w12, CS significantly (P < .05) reduced MMP‐9 immunoreactive positivity and intensity in the extracellular matrix, while increasing total collagen amount in the extracellular matrix; and 4) CS treatment significantly (P < .01) reduced the number of eosinophils and their MMP and TIMP‐1 immunoreactive expression.
Conclusions
CS treatment modulates NP mucosa remodeling, particularly by promoting epithelial repair, regulating tissue remodeling markers, increasing total collagen content, and reducing tissue eosinophil infiltration.
Level of Evidence
4 Laryngoscope, 125:E158–E167, 2015</description><subject>Administration, Intranasal</subject><subject>Administration, Oral</subject><subject>Biopsy</subject><subject>Budesonide - administration & dosage</subject><subject>Chronic Disease</subject><subject>chronic rhinosinusitis with nasal polyp</subject><subject>Collagen</subject><subject>Collagenases - biosynthesis</subject><subject>Corticosteroids</subject><subject>Drug Therapy, Combination</subject><subject>eosinophilic inflammation</subject><subject>Eosinophils - pathology</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>matrix metalloproteases</subject><subject>Middle Aged</subject><subject>Nasal Mucosa - enzymology</subject><subject>Nasal Mucosa - pathology</subject><subject>Nasal Polyps - complications</subject><subject>Nasal Polyps - drug therapy</subject><subject>Nasal Polyps - pathology</subject><subject>Prednisone - administration & dosage</subject><subject>remodeling</subject><subject>Retrospective Studies</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - drug therapy</subject><subject>Rhinitis - pathology</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - drug therapy</subject><subject>Sinusitis - pathology</subject><subject>Tissue Inhibitor of Metalloproteinases - biosynthesis</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi0EoqFw4QeglbggpG397d1jFdG0UkorVAScLGd30rh47WB7VfLv623aHjhwssbzzCv7GYTeE3xEMKbHzsTdERWEqxdoRgQjNW9b8RLNSpPVjaA_D9CblG4xJooJ_BodUCE5EZjOkJmHmG0XUoYYbF_lCCYP4HMV4WZ0JkOqhrH0jSs3Q-jBWX9TWV91mxi87aq4sT4k68dks03Vnc2bypuJ3wa326a36NXauATvHs9D9P30y_X8rF5eLs7nJ8u641Ko2nDGGsJ6w7iQdNUA70vRK-gllaIB0vWk5etGmg5WxoBRtKflF4w3WDDF2SH6tM_dxvBnhJT1YFMHzhkPYUyaSCVFSxRlBf34D3obxujL6yZKNJxTNVGf91QXQ0oR1nob7VBca4L1JF5P4vWD-AJ_eIwcVwP0z-iT6QKQPXBnHez-E6WXJ99-PYXW-xlb1vP3ecbE31oqpoT-8XWhr8ni6uL0qtVn7B7zmJ6j</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>de Borja Callejas, Francisco</creator><creator>Martínez-Antón, Asunción</creator><creator>Picado, César</creator><creator>Alobid, Isam</creator><creator>Pujols, Laura</creator><creator>Valero, Antonio</creator><creator>Roca-Ferrer, Jordi</creator><creator>Mullol, Joaquim</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps</title><author>de Borja Callejas, Francisco ; Martínez-Antón, Asunción ; Picado, César ; Alobid, Isam ; Pujols, Laura ; Valero, Antonio ; Roca-Ferrer, Jordi ; Mullol, Joaquim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4657-a433813da34562b8e4d3dad7ed62658e1cd194f86acebaaea72d2641348053743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Intranasal</topic><topic>Administration, Oral</topic><topic>Biopsy</topic><topic>Budesonide - administration & dosage</topic><topic>Chronic Disease</topic><topic>chronic rhinosinusitis with nasal polyp</topic><topic>Collagen</topic><topic>Collagenases - biosynthesis</topic><topic>Corticosteroids</topic><topic>Drug Therapy, Combination</topic><topic>eosinophilic inflammation</topic><topic>Eosinophils - pathology</topic><topic>Extracellular matrix</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>matrix metalloproteases</topic><topic>Middle Aged</topic><topic>Nasal Mucosa - enzymology</topic><topic>Nasal Mucosa - pathology</topic><topic>Nasal Polyps - complications</topic><topic>Nasal Polyps - drug therapy</topic><topic>Nasal Polyps - pathology</topic><topic>Prednisone - administration & dosage</topic><topic>remodeling</topic><topic>Retrospective Studies</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - drug therapy</topic><topic>Rhinitis - pathology</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - drug therapy</topic><topic>Sinusitis - pathology</topic><topic>Tissue Inhibitor of Metalloproteinases - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Borja Callejas, Francisco</creatorcontrib><creatorcontrib>Martínez-Antón, Asunción</creatorcontrib><creatorcontrib>Picado, César</creatorcontrib><creatorcontrib>Alobid, Isam</creatorcontrib><creatorcontrib>Pujols, Laura</creatorcontrib><creatorcontrib>Valero, Antonio</creatorcontrib><creatorcontrib>Roca-Ferrer, Jordi</creatorcontrib><creatorcontrib>Mullol, Joaquim</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Borja Callejas, Francisco</au><au>Martínez-Antón, Asunción</au><au>Picado, César</au><au>Alobid, Isam</au><au>Pujols, Laura</au><au>Valero, Antonio</au><au>Roca-Ferrer, Jordi</au><au>Mullol, Joaquim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2015-05</date><risdate>2015</risdate><volume>125</volume><issue>5</issue><spage>E158</spage><epage>E167</epage><pages>E158-E167</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP).
Study Design
Case series, retrospective study.
Methods
Patients (n = 18) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP‐1), MMP‐2, MMP‐7, MMP‐9, and tissue inhibitor of metalloprotease type 1 (TIMP‐1) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment.
Results
Compared to w0: 1) oral plus intranasal CS significantly (P < .01) increased presence of submucosal glands at w2, decreased epithelial cell hyperplasia at w12, and decreased tissue eosinophilia at w2 and w12; 2) CS treatment significantly (P < .05) increased immunoreactivity for MMP‐1 and MMP‐2 in the epithelium at w2, but decreased immunoreactivity for MMP‐9 in the epithelium at w2 and w12; 3) at w12, CS significantly (P < .05) reduced MMP‐9 immunoreactive positivity and intensity in the extracellular matrix, while increasing total collagen amount in the extracellular matrix; and 4) CS treatment significantly (P < .01) reduced the number of eosinophils and their MMP and TIMP‐1 immunoreactive expression.
Conclusions
CS treatment modulates NP mucosa remodeling, particularly by promoting epithelial repair, regulating tissue remodeling markers, increasing total collagen content, and reducing tissue eosinophil infiltration.
Level of Evidence
4 Laryngoscope, 125:E158–E167, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25641502</pmid><doi>10.1002/lary.25147</doi><tpages>10</tpages></addata></record> |
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| subjects | Administration, Intranasal Administration, Oral Biopsy Budesonide - administration & dosage Chronic Disease chronic rhinosinusitis with nasal polyp Collagen Collagenases - biosynthesis Corticosteroids Drug Therapy, Combination eosinophilic inflammation Eosinophils - pathology Extracellular matrix Female Glucocorticoids - administration & dosage Humans Immunohistochemistry Male matrix metalloproteases Middle Aged Nasal Mucosa - enzymology Nasal Mucosa - pathology Nasal Polyps - complications Nasal Polyps - drug therapy Nasal Polyps - pathology Prednisone - administration & dosage remodeling Retrospective Studies Rhinitis - complications Rhinitis - drug therapy Rhinitis - pathology Sinusitis - complications Sinusitis - drug therapy Sinusitis - pathology Tissue Inhibitor of Metalloproteinases - biosynthesis |
| title | Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps |
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