Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps

Objectives/Hypothesis To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). Study Design Case series, retrospective study. Methods Patients (n = 18) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP‐1), MMP‐2, MMP‐7, MMP‐9, and tissue inhibitor of metalloprotease type 1 (TIMP‐1) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment. Results Compared to w0: 1) oral plus intranasal CS significantly (P