First-trimester combined screening for trisomy 21 in women with renal disease

Objective To evaluate the results of first‐trimester combined screening for Down syndrome in women with chronic renal disease. Method Fifty‐five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, and gestational age. Maternal...

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Veröffentlicht in:	Prenatal diagnosis 2015-03, Vol.35 (3), p.244-248
Hauptverfasser:	Valentin, Morgane, Muller, Françoise, Beaujard, Marie Paule, Dreux, Sophie, Czerkiewicz, Isabelle, Meyer, Valérie, Leruez, Marianne, Ville, Yves, Salomon, Laurent J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - metabolism Case-Control Studies Chorionic Gonadotropin, beta Subunit, Human - metabolism Cohort Studies Creatinine - metabolism Down Syndrome - blood Down Syndrome - diagnosis Down Syndrome - diagnostic imaging False Positive Reactions Female Gestational Age Humans Maternal Age Nuchal Translucency Measurement Pregnancy Pregnancy Complications - metabolism Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A - metabolism Prenatal Diagnosis Renal Insufficiency, Chronic - metabolism Retrospective Studies Ultrasonography, Prenatal Young Adult
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Zusammenfassung:	Objective To evaluate the results of first‐trimester combined screening for Down syndrome in women with chronic renal disease. Method Fifty‐five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, and gestational age. Maternal renal function was assayed at the time of the combined screening, and renal insufficiency was defined by serum creatinine >90 µmol/L and renal clearance
ISSN:	0197-3851 1097-0223
DOI:	10.1002/pd.4528