Revisiting tissue specificity of germline cancer predisposing mutations
Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction? Heritable germline mutations in major cancer genes generally lead to a restricte...
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| Veröffentlicht in: | Nature reviews. Cancer 2015-02, Vol.15 (2), p.65-66 |
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| container_title | Nature reviews. Cancer |
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| creator | Maris, John M. Knudson, Alfred G. |
| description | Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction?
Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults? |
| doi_str_mv | 10.1038/nrc3894 |
| format | Article |
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Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. 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Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maris, John M.</au><au>Knudson, Alfred G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Revisiting tissue specificity of germline cancer predisposing mutations</atitle><jtitle>Nature reviews. Cancer</jtitle><stitle>Nat Rev Cancer</stitle><addtitle>Nat Rev Cancer</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>15</volume><issue>2</issue><spage>65</spage><epage>66</epage><pages>65-66</pages><issn>1474-175X</issn><eissn>1474-1768</eissn><abstract>Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction?
Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25688405</pmid><doi>10.1038/nrc3894</doi><tpages>2</tpages></addata></record> |
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| subjects | 631/67/1678 631/67/2332 Adult Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic - genetics Child Childhood cancer comment Gene mutation Genes, Wilms Tumor Genetic aspects Genetic Predisposition to Disease Germ-Line Mutation Health aspects Humans Neuroblastoma - genetics Organ Specificity - genetics Receptor Protein-Tyrosine Kinases - genetics Retinoblastoma - genetics Retinoblastoma Protein - genetics Risk factors Tumor Suppressor Protein p53 - genetics |
| title | Revisiting tissue specificity of germline cancer predisposing mutations |
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