Revisiting tissue specificity of germline cancer predisposing mutations

Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction? Heritable germline mutations in major cancer genes generally lead to a restricte...

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Veröffentlicht in:	Nature reviews. Cancer 2015-02, Vol.15 (2), p.65-66
Hauptverfasser:	Maris, John M., Knudson, Alfred G.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1678 631/67/2332 Adult Biomedical and Life Sciences Biomedicine Cancer Research Cell Transformation, Neoplastic - genetics Child Childhood cancer comment Gene mutation Genes, Wilms Tumor Genetic aspects Genetic Predisposition to Disease Germ-Line Mutation Health aspects Humans Neuroblastoma - genetics Organ Specificity - genetics Receptor Protein-Tyrosine Kinases - genetics Retinoblastoma - genetics Retinoblastoma Protein - genetics Risk factors Tumor Suppressor Protein p53 - genetics
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Zusammenfassung:	Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction? Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc3894