Inhibitory effect of Psidium guajava water extract in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice
► Psidium guajava water extract inhibits 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like skin lesions in mice. ► PGW suppresses DNCB-induced dermatitis intensity scores, levels of IgE, TARC, TNF-α, and IL-4 in serum and ears. ► PGW suppresses DNCB-induced thickness of the epidermis/de...
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Veröffentlicht in: | Food and chemical toxicology 2012-08, Vol.50 (8), p.2923-2929 |
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Sprache: | eng |
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Zusammenfassung: | ► Psidium guajava water extract inhibits 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like skin lesions in mice. ► PGW suppresses DNCB-induced dermatitis intensity scores, levels of IgE, TARC, TNF-α, and IL-4 in serum and ears. ► PGW suppresses DNCB-induced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears.
Atopic dermatitis (AD) is a chronic, relapsing, and inflammatory skin disease associated with eczematous symptoms and IgE hyperproduction. Psidium guajava is an important food crop and medicinal plant with anti-oxidant, anti-inflammatory, and anti-allergic activities, supporting its traditional uses. Our previous studies have shown that P. guajava extract inhibits Th2 chemokine expression by suppressing the activation of NF-κB and STAT1 co-stimulated with TNF-α and INF-γ. In this study, we investigated the inhibitory effect of P. guajava water extract (PGW) on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in NC/Nga mice. Treatment of cream containing PGW onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, PGW increased level of the immunosuppressive cytokine IL-10. Histological analyses demonstrated decreased thickening of the epidermis/dermis as well as dermal infiltration by inflammatory cells. These results suggest that cream containing PGW may be a potential therapeutic modality for AD and adjunctive agent to control pruritus in AD. |
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ISSN: | 0278-6915 1873-6351 |
DOI: | 10.1016/j.fct.2012.04.044 |