Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence

Highlights • We carried out a meta-analysis for 6 candidate genes and alcohol dependence. • We included 42 original studies and three models were tested. • We did not find significant pooled odds ratios for any of the six candidate genes. • Future studies of novel genes could identify further molecu...

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Veröffentlicht in:	Drug and alcohol dependence 2015-04, Vol.149, p.259-263
Hauptverfasser:	Forero, Diego A, López-León, Sandra, Shin, Hyoung Doo, Park, Byung Lae, Kim, Dai-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Adolescent Adult Alcoholism Alcoholism - genetics Brain-Derived Neurotrophic Factor - genetics Candidate genes Female Genetic Predisposition to Disease - genetics Humans Male Middle Aged Models, Genetic Monoamine Oxidase - genetics Neurogenetics Neuronal Plasticity - genetics Psychiatry Receptors, Dopamine D1 - genetics Receptors, Dopamine D3 - genetics Receptors, Dopamine D4 - genetics Receptors, N-Methyl-D-Aspartate - genetics Synaptic Transmission - genetics Young Adult
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Beschreibung
Zusammenfassung:	Highlights • We carried out a meta-analysis for 6 candidate genes and alcohol dependence. • We included 42 original studies and three models were tested. • We did not find significant pooled odds ratios for any of the six candidate genes. • Future studies of novel genes could identify further molecular factors.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2015.01.017