Antenatal Maternal Anxiety Predicts Variations in Neural Structures Implicated in Anxiety Disorders in Newborns

Objective Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and asse...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Academy of Child and Adolescent Psychiatry 2015-04, Vol.54 (4), p.313-321.e2
Hauptverfasser:	Rifkin-Graboi, Anne, PhD, Meaney, Michael J., PhD, Chen, Helen, MBBS, Bai, Jordan, BEng, Hameed, Waseem Bak’r, BS, Tint, Mya Thway, MSc, Broekman, Birit F.P., MD, PhD, Chong, Yap-Seng, MD, Gluckman, Peter D., KNZM, FRSNZ, FMedSci, FRS, Fortier, Marielle V., MD, FRCP, Qiu, Anqi, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective Behavior Anisotropy antenatal anxiety Anxiety Anxiety - physiopathology Anxiety Disorders Anxiety Disorders - diagnosis Anxiety Disorders - physiopathology axial diffusivity Babies Brain Brain - pathology Cognition & reasoning Depression Diffusion Tensor Imaging Emotional Response Emotions Female fractional anisotropy Humans Infant Infant, Newborn Linear Models Longitudinal Studies Magnetic Resonance Imaging Male Mothers - psychology neonatal brain Neonates Pediatrics Pregnancy Pregnancy Complications - psychology Prenatal Exposure Delayed Effects Psychiatric Status Rating Scales Psychiatry Psychological Patterns Psychopathology Singapore Young Children
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Objective Antenatal maternal anxiety predicts offspring neurodevelopment and psychopathology, although the degree to which these associations reflect postnatal influences is unclear. To limit this possibility, we assessed newborn neuronal microstructures using diffusion tensor imaging (DTI) and assessed neonatal microstructure variation in relation to antenatal anxiety and in prediction of infant socio-emotional behavior at age 1 year. Method Dyads were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort, and included mothers who completed the Speilberger State-Trait Anxiety Inventory (STAI) at 26 weeks gestation (scoring >90, n = 20; scoring
ISSN:	0890-8567 1527-5418
DOI:	10.1016/j.jaac.2015.01.013