Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

► Caffeine distribute and accumulate in rat adipose, brain and serum. ► Caffeine inhibit the SSAO activity in all rat tissues. ► Efficiency of caffeine on adipose and aorta was high. Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2012-10, Vol.33 (5), p.1248-1253
Hauptverfasser:	Che, Baoquan, Wang, Lin, Zhang, Zhe, Zhang, Yongqian, Deng, Yulin
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adipose Tissue - drug effects Adipose Tissue - enzymology Amine Oxidase (Copper-Containing) - metabolism Animals Aorta - drug effects Aorta - enzymology Biological and medical sciences Brain - drug effects Brain - enzymology Caffeine Caffeine - blood Caffeine - pharmacokinetics Central Nervous System Stimulants - blood Central Nervous System Stimulants - pharmacokinetics Chromatography, High Pressure Liquid Distribution Ethylamines - pharmacology Inhibitor Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Male Medical sciences Rats Rats, Wistar SSAO Statistics, Nonparametric Tandem Mass Spectrometry Time Factors Tissue Distribution - drug effects Toxicology
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Zusammenfassung:	► Caffeine distribute and accumulate in rat adipose, brain and serum. ► Caffeine inhibit the SSAO activity in all rat tissues. ► Efficiency of caffeine on adipose and aorta was high. Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC–MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.
ISSN:	0161-813X 1872-9711
DOI:	10.1016/j.neuro.2012.07.004