CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens

CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens

Highlights ► Increasing antigen dose can overcome the reported deficiency of CCR9−/− mice to develop normal immune tolerance to oral antigens. ► The CCR9 antagonist, CCX507, does not affect the ability of mice to develop normal immune tolerance to oral antigens. ► The results obtained in CCR9−/− mic...

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Veröffentlicht in:Immunology letters 2013-03, Vol.151 (1), p.44-47
Hauptverfasser: Walters, Matthew J, Ebsworth, Karen, Sullivan, Timothy J, Zhang, Penglie, Powers, Jay P, Jaen, Juan C, Schall, Thomas J
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Allergy and Immunology
Animals
Antigens - administration & dosage
Antigens - immunology
CCR9
Chemokine
Immune Tolerance - immunology
Mice
Mice, Knockout
Oral tolerance
Ovalbumin - immunology
Receptors, CCR - antagonists & inhibitors
Receptors, CCR - genetics
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Zusammenfassung:Highlights ► Increasing antigen dose can overcome the reported deficiency of CCR9−/− mice to develop normal immune tolerance to oral antigens. ► The CCR9 antagonist, CCX507, does not affect the ability of mice to develop normal immune tolerance to oral antigens. ► The results obtained in CCR9−/− mice do not necessarily predict the results of pharmacological inhibition of CCR9.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.01.006