Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma

► Mangosteen xanthones reverse pathophysiological features of ovalbumin-induced mouse asthma model. ► Suppression of PI3K, Akt, and PTEN are involved in mitigating allergic asthma. ► The present results suggest potentials of α-and γ-mangostins as anti-asthmatic substances. α- and γ-Mangostin, which are the major xanthones purified from a Mangosteen, Garcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities. Here, we assessed their therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Animals were treated with α- and γ-mangostins orally for 3days at doses of 10 and 30mg/kg daily, 1h before the OVA challenge. Administration of α- and γ-mangostins significantly reduced the major pathophysiological features of allergic asthma, including inflammatory cell recruitment into the airway, airway hyperresponsiveness (AHR), and increased levels of Th2 cytokines. In addition, α- and γ-mangostins attenuated the increases in phosphoinositide 3-kinase (PI3K) activity, phosphorylation of Akt, and NF-κB in nuclear protein extracts after OVA challenge. In conclusion, α- and γ-mangostin may have therapeutic potential for the treatment of allergic asthma.