Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β

The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still remain obscure. We investigated the relationship between STAT3 and glycogen synthase kinase‐3β (GSK‐...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2015-05, Vol.123 (5), p.373-382
Hauptverfasser:	Yoon, Jiyeon, Ko, Young San, Cho, Sung Jin, Park, Jinju, Choi, Young Sun, Choi, Yiseul, Pyo, Jung-Soo, Ye, Sang-Kyu, Youn, Hong-Duk, Lee, Jae-Seon, Chang, Mee Soo, Kim, Min A, Lee, Byung Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Movement - physiology Epithelial-Mesenchymal Transition - physiology gastric cancer Gene Knockdown Techniques Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK-3β Humans Immunohistochemistry invasion migration Mutant Proteins - genetics Mutant Proteins - metabolism Neoplasm Invasiveness - physiopathology RNA, Small Interfering - genetics Signal Transduction STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - secondary Thiazoles - pharmacology Tyrphostins - pharmacology Urea - analogs & derivatives Urea - pharmacology
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