Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β

The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still remain obscure. We investigated the relationship between STAT3 and glycogen synthase kinase‐3β (GSK‐...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2015-05, Vol.123 (5), p.373-382
Hauptverfasser:	Yoon, Jiyeon, Ko, Young San, Cho, Sung Jin, Park, Jinju, Choi, Young Sun, Choi, Yiseul, Pyo, Jung-Soo, Ye, Sang-Kyu, Youn, Hong-Duk, Lee, Jae-Seon, Chang, Mee Soo, Kim, Min A, Lee, Byung Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Movement - physiology Epithelial-Mesenchymal Transition - physiology gastric cancer Gene Knockdown Techniques Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK-3β Humans Immunohistochemistry invasion migration Mutant Proteins - genetics Mutant Proteins - metabolism Neoplasm Invasiveness - physiopathology RNA, Small Interfering - genetics Signal Transduction STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - secondary Thiazoles - pharmacology Tyrphostins - pharmacology Urea - analogs & derivatives Urea - pharmacology
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Zusammenfassung:	The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still remain obscure. We investigated the relationship between STAT3 and glycogen synthase kinase‐3β (GSK‐3β) and its significance in metastatic potential in gastric cancer cells. Immunohistochemical tissue array analysis of 267 human gastric carcinoma specimens showed that the expressions of active forms of STAT3 (pSTAT3) and GSK‐3β (pGSK‐3β) were found in 68 (25%) and 124 (46%) of 267 gastric cancer cases, respectively, showing a positive correlation (p
ISSN:	0903-4641 1600-0463
DOI:	10.1111/apm.12370