The serum estradiol concentration is the main determinant of the estradiol concentration in normal breast tissue

Highlights • This study shows that serum estradiol levels largely determine estrogen levels in normal breast tissue. • This study shows that tamoxifen induces high levels of estrogen in the serum and in the breast in premenopausal women. • High levels of estrogen may be dangerous in women with a hig...

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Veröffentlicht in:	Maturitas 2015-05, Vol.81 (1), p.42-45
Hauptverfasser:	Depypere, H.T, Bolca, S, Bracke, M, Delanghe, J, Comhaire, F, Blondeel, Ph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic Agents, Hormonal - therapeutic use Aromatase inhibitor Aromatase Inhibitors - therapeutic use Breast - chemistry Breast epithelium Breast Neoplasms - drug therapy Breast Neoplasms - surgery Contraceptives, Oral Estradiol - analysis Estradiol - blood Estradiol concentration Female Humans Internal Medicine Middle Aged Obstetrics and Gynecology Postmenopause - blood Premenopause - blood Tamoxifen Tamoxifen - therapeutic use Young Adult
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Beschreibung
Zusammenfassung:	Highlights • This study shows that serum estradiol levels largely determine estrogen levels in normal breast tissue. • This study shows that tamoxifen induces high levels of estrogen in the serum and in the breast in premenopausal women. • High levels of estrogen may be dangerous in women with a high risk for relapse.
ISSN:	0378-5122 1873-4111
DOI:	10.1016/j.maturitas.2015.01.014