New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-04, Vol.58 (8), p.3329-3339
Hauptverfasser:	de Souza, Diego, Mariano, Douglas O. C, Nedel, Fernanda, Schultze, Eduarda, Campos, Vinícius F, Seixas, Fabiana, da Silva, Rafael S, Munchen, Taiana S, Ilha, Vinicius, Dornelles, Luciano, Braga, Antonio L, Rocha, João B. T, Collares, Tiago, Rodrigues, Oscar E. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Apoptosis - drug effects Cell Line, Tumor Chalcogens - chemical synthesis Chalcogens - chemistry Chalcogens - pharmacology Humans Male Rats, Wistar Thiobarbituric Acid Reactive Substances - metabolism Urinary Bladder - drug effects Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Zidovudine - chemical synthesis Zidovudine - chemistry Zidovudine - pharmacology
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