New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A...

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Veröffentlicht in:Journal of medicinal chemistry 2015-04, Vol.58 (8), p.3329-3339
Hauptverfasser: de Souza, Diego, Mariano, Douglas O. C, Nedel, Fernanda, Schultze, Eduarda, Campos, Vinícius F, Seixas, Fabiana, da Silva, Rafael S, Munchen, Taiana S, Ilha, Vinicius, Dornelles, Luciano, Braga, Antonio L, Rocha, João B. T, Collares, Tiago, Rodrigues, Oscar E. D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidants - chemical synthesis
Antioxidants - chemistry
Antioxidants - pharmacology
Apoptosis - drug effects
Cell Line, Tumor
Chalcogens - chemical synthesis
Chalcogens - chemistry
Chalcogens - pharmacology
Humans
Male
Rats, Wistar
Thiobarbituric Acid Reactive Substances - metabolism
Urinary Bladder - drug effects
Urinary Bladder - metabolism
Urinary Bladder - pathology
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - metabolism
Urinary Bladder Neoplasms - pathology
Zidovudine - chemical synthesis
Zidovudine - chemistry
Zidovudine - pharmacology
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Zusammenfassung:In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm5015296