Efficacy, safety and pharmacokinetics of sugammadex 4 mg kg−1 for reversal of deep neuromuscular blockade in patients with severe renal impairment

This study evaluated efficacy and safety of sugammadex 4 mg kg−1 for deep neuromuscular blockade (NMB) reversal in patients with severe renal impairment (creatinine clearance [CLCR]

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Veröffentlicht in:	British journal of anaesthesia : BJA 2015-05, Vol.114 (5), p.777-784
Hauptverfasser:	Panhuizen, I.F., Gold, S.J.A., Buerkle, C., Snoeck, M.M.J., Harper, N.J.N., Kaspers, M.J.G.H., van den Heuvel, M.W., Hollmann, M.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstanols - antagonists & inhibitors Blood Pressure - drug effects Female gamma-Cyclodextrins - adverse effects gamma-Cyclodextrins - pharmacokinetics Heart Rate - drug effects Humans Male Middle Aged neuromuscular blockade Neuromuscular Blockade - methods Neuromuscular Nondepolarizing Agents - antagonists & inhibitors Pain - chemically induced renal failure Renal Insufficiency - surgery rocuronium sugammadex Treatment Outcome
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Beschreibung
Zusammenfassung:	This study evaluated efficacy and safety of sugammadex 4 mg kg−1 for deep neuromuscular blockade (NMB) reversal in patients with severe renal impairment (creatinine clearance [CLCR]
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/aet586