Regioselective Synthesis and Antiviral Activity of Purine Nucleoside Analogues with Acyclic Substituents at N7

A new class of antiviral compounds is heralded by purine derivative 1, which in vitro tests showed to have good antiherpes action. This compound proves that, like the natural purine nucleosides with a cyclic residue at N9, derivatives with an acyclic substituent at N7 can also be active.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 1994-03, Vol.33 (5), p.562-563
Hauptverfasser:	Jähne, Gerhard, Kroha, Herbert, Müller, Armin, Helsberg, Matthias, Winkler, Irvin, Gross, Gerhard, Scholl, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates. Nucleosides and nucleotides Chemistry Exact sciences and technology Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new class of antiviral compounds is heralded by purine derivative 1, which in vitro tests showed to have good antiherpes action. This compound proves that, like the natural purine nucleosides with a cyclic residue at N9, derivatives with an acyclic substituent at N7 can also be active.
ISSN:	0570-0833 1521-3773
DOI:	10.1002/anie.199405621