Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

Highlights • Ischaemic brain injury leads to excitotoxicity and cell death. • The glutamatergic transmission via synaptic NMDA receptors is neuroprotective. • Non-synaptic NMDA receptors (composed of GluN2B subunits) are excitotoxic. • Selective inhibition of non-synaptic NMDARs may be beneficial. •...

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Veröffentlicht in:	Brain research bulletin 2015-03, Vol.112, p.1-6
Hauptverfasser:	Brassai, A, Suvanjeiev, R.-G, Bán, E.-Gy, Lakatos, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catecholamine Cell Death - physiology Glutamate Humans Ischaemia Ischemia - physiopathology Mechanism Neurology Neurons - physiology Receptors, Glutamate - metabolism Stroke Synapses - physiology
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Beschreibung
Zusammenfassung:	Highlights • Ischaemic brain injury leads to excitotoxicity and cell death. • The glutamatergic transmission via synaptic NMDA receptors is neuroprotective. • Non-synaptic NMDA receptors (composed of GluN2B subunits) are excitotoxic. • Selective inhibition of non-synaptic NMDARs may be beneficial. • Oxygen–glucose deprivation mimics ischaemic conditions.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.12.007