The Molecular Landscape of Antibody‐Mediated Kidney Transplant Rejection: Evidence for NK Involvement Through CD16a Fc Receptors

The recent recognition that antibody‐mediated rejection (ABMR) is the major cause of kidney transplant loss creates strong interest in its pathogenesis. We used microarray analysis of kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR transcript changes in the in...

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Veröffentlicht in:	American journal of transplantation 2015-05, Vol.15 (5), p.1336-1348
Hauptverfasser:	Venner, J. M., Hidalgo, L. G., Famulski, K. S., Chang, J., Halloran, P. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Algorithms Antibodies - chemistry basic (laboratory) research / science Biopsy CD4-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology Chemokines Cohort Studies Cytotoxicity Databases, Factual Female Graft Rejection Human Umbilical Vein Endothelial Cells Humans Kidney Diseases - pathology Kidney Diseases - surgery Kidney Transplantation kidney transplantation / nephrology Killer Cells, Natural - cytology Macrophages - metabolism Male Microcirculation Middle Aged natural killer (NK) cells / NK receptors Receptors, IgG - metabolism rejection: antibody‐mediated (ABMR) Rodents signaling / signaling pathways Transplants & implants Young Adult
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