The Molecular Landscape of Antibody‐Mediated Kidney Transplant Rejection: Evidence for NK Involvement Through CD16a Fc Receptors

The Molecular Landscape of Antibody‐Mediated Kidney Transplant Rejection: Evidence for NK Involvement Through CD16a Fc Receptors

The recent recognition that antibody‐mediated rejection (ABMR) is the major cause of kidney transplant loss creates strong interest in its pathogenesis. We used microarray analysis of kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR transcript changes in the in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of transplantation 2015-05, Vol.15 (5), p.1336-1348
Hauptverfasser: Venner, J. M., Hidalgo, L. G., Famulski, K. S., Chang, J., Halloran, P. F.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Antibodies - chemistry
basic (laboratory) research / science
Biopsy
CD4-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - cytology
Chemokines
Cohort Studies
Cytotoxicity
Databases, Factual
Female
Graft Rejection
Human Umbilical Vein Endothelial Cells
Humans
Kidney Diseases - pathology
Kidney Diseases - surgery
Kidney Transplantation
kidney transplantation / nephrology
Killer Cells, Natural - cytology
Macrophages - metabolism
Male
Microcirculation
Middle Aged
natural killer (NK) cells / NK receptors
Receptors, IgG - metabolism
rejection: antibody‐mediated (ABMR)
Rodents
signaling / signaling pathways
Transplants & implants
Young Adult
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The recent recognition that antibody‐mediated rejection (ABMR) is the major cause of kidney transplant loss creates strong interest in its pathogenesis. We used microarray analysis of kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR transcript changes in the initial Discovery Set were strongly conserved in a subsequent Validation Set. In the Combined Set of 703 biopsies, 2603 transcripts were significantly changed (FDR 
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.13115