Cloning and structural analysis of genomic DNA for human renal dipeptidase

A genomic DNA for human renal dipeptidase was isolated from a human genomic library using probes for human renal dipeptidase cDNA. The human renal dipeptidase gene, containing ten exons and nine introns, had a total length of approx. 6 kbp. The DNA sequence of these exons was slightly different from...

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Veröffentlicht in:	Biochimica et biophysica acta 1993-02, Vol.1172 (1), p.181-183
Hauptverfasser:	Satoh, Susumu, Kusunoki, Chihiro, Konta, Yoshiyuki, Niwa, Mineo, Kohsaka, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences cDNA Cloning, Molecular dipeptidase Dipeptidases - genetics DNA - genetics DNA cloning DNA sequence Exons Fundamental and applied biological sciences. Psychology genes Genes. Genome genomic DNA Genomic Library Human Humans kidney Kidney - enzymology man membrane dipeptidase Molecular and cellular biology Molecular genetics Molecular Sequence Data nucleotide sequence predictions Renal dipeptidase Restriction Mapping TATA Box
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Zusammenfassung:	A genomic DNA for human renal dipeptidase was isolated from a human genomic library using probes for human renal dipeptidase cDNA. The human renal dipeptidase gene, containing ten exons and nine introns, had a total length of approx. 6 kbp. The DNA sequence of these exons was slightly different from that of the human renal dipeptidase cDNA reported by Adachi et al. [1]. From the results of a comparison of the deduced amino acid sequence of each exon with various mammalian renal dipeptidases, the fourth exon was found to be highly conserved (90%).
ISSN:	0167-4781 0006-3002 1879-2634
DOI:	10.1016/0167-4781(93)90289-P