Aberrant expression of the CHFR prophase checkpoint gene in human B-cell non-Hodgkin lymphoma

Highlights • The expression of CHFR was reduced in B-NHL tissue samples and B cell lines. • CHFR methylation correlated with CHFR downregulation and progression for B-NHL. • Demethylation reagent, 5-Aza-dC or CHFR overexpression inhibited B cell growth.

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Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2015-05, Vol.39 (5), p.536-543
Hauptverfasser:	Song, Aiqin, Ye, Junli, Zhang, Kunpeng, Yu, Hongsheng, Gao, Yanhua, Wang, Hongfang, Sun, Lirong, Xing, Xiaoming, Yang, Kun, Zhao, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over B-cell non-Hodgkin lymphoma Cell Cycle Checkpoints - genetics Cell Cycle Proteins - genetics Cell Line, Tumor CHFR Child Child, Preschool DNA Methylation Female Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Lymphoma, B-Cell - genetics Lymphoma, B-Cell - pathology Male Methylation Middle Aged Neoplasm Proteins - genetics Poly-ADP-Ribose Binding Proteins Prophase - genetics Raji cell Ubiquitin-Protein Ligases Young Adult
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Beschreibung
Zusammenfassung:	Highlights • The expression of CHFR was reduced in B-NHL tissue samples and B cell lines. • CHFR methylation correlated with CHFR downregulation and progression for B-NHL. • Demethylation reagent, 5-Aza-dC or CHFR overexpression inhibited B cell growth.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.02.007