Trichoharzianol, a New Antifungal from Trichoderma harzianum F031

A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2–4 were reported fro...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2015-04, Vol.63 (14), p.3704-3708
Hauptverfasser:	Jeerapong, Chotika, Phupong, Worrapong, Bangrak, Phuwadol, Intana, Warin, Tuchinda, Patoomratana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - metabolism Antifungal Agents - pharmacology Colletotrichum - drug effects Microbial Sensitivity Tests Naphthalenes - chemistry Naphthalenes - metabolism Naphthalenes - pharmacology Trichoderma - chemistry Trichoderma - metabolism
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Beschreibung
Zusammenfassung:	A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2–4 were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (1) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL.
ISSN:	0021-8561 1520-5118
DOI:	10.1021/acs.jafc.5b01258