A review of the equine age-related changes in the immune system: Comparisons between human and equine aging, with focus on lung-specific immune-aging

A review of the equine age-related changes in the immune system: Comparisons between human and equine aging, with focus on lung-specific immune-aging

Highlights • COPD in humans and RAO in horses share many similarities. • Evidence for a central role for the alveolar macrophages in aging and disease. • Evidence of lung-specific aging. • Evidence of a more tight regulation of cytokines within the lungs.

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Bibliographische Detailangaben
Veröffentlicht in:Ageing research reviews 2015-03, Vol.20, p.11-23
Hauptverfasser: Hansen, S, Baptiste, K.E, Fjeldborg, J, Horohov, D.W
Format: Artikel
Sprache:eng
Schlagworte:
Aging - immunology
Animals
Cytokines - blood
Environmental Exposure - adverse effects
Horses
Humans
Immune System - physiology
Immune System - physiopathology
Immunity - physiology
Internal Medicine
Lung - immunology
Lung - physiopathology
Neurology
Organ Specificity
Oxidative Stress - immunology
T-Lymphocytes - metabolism
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Beschreibung
Zusammenfassung:Highlights • COPD in humans and RAO in horses share many similarities. • Evidence for a central role for the alveolar macrophages in aging and disease. • Evidence of lung-specific aging. • Evidence of a more tight regulation of cytokines within the lungs.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2014.12.002