Merlin's wizardry guides cohesive migration

Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin–Rich1 complex and t...

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Veröffentlicht in:	Nature cell biology 2015-03, Vol.17 (3), p.212-213
Hauptverfasser:	Zoch, Ansgar, Morrison, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/79/2066 631/80/84/2334 631/80/85 631/80/86/2341 Animals Cancer Research Cell Biology Cell migration Cellular control mechanisms Developmental Biology Genetic aspects Humans Keratinocytes - metabolism Life Sciences Mechanotransduction, Cellular - genetics Neurofibromin 2 - metabolism news-and-views Properties Pseudopodia - metabolism rac1 GTP-Binding Protein - metabolism Stem Cells Tumor suppressor genes
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Beschreibung
Zusammenfassung:	Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin–Rich1 complex and the Rac1 small GTPase.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb3126