Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

The 39-43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer's disease (AD), is released by cultured human cells during normal metabolism. Here we show that agents which activate protein kinase C or otherwise enhance pro...

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Veröffentlicht in:	The Journal of biological chemistry 1993-11, Vol.268 (31), p.22959-22962
Hauptverfasser:	HUNG, A. Y, HAASS, C, NITSCH, R. M, WEI QIAO QIU, CITRON, M, WURTMAN, R. J, GROWDON, J. H, SELKOE, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid beta-Peptides - biosynthesis Biological and medical sciences Cell Line Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme Activation Ethers, Cyclic - pharmacology Humans In Vitro Techniques Medical sciences Molecular Sequence Data Neurology Okadaic Acid Phorbol Esters - pharmacology Phosphoproteins - physiology Protein Kinase C - physiology Receptors, Muscarinic - physiology Type C Phospholipases - metabolism
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