A study of family clustering in two young girls with novel avian influenza A (H7N9) in Dongyang, Zhejiang Province, in 2014

Highlights • We reported a family clustering case for two girls in Zhejiang Province, China. • The index patient with higher level of cytokines suffered more serious infection. • Significant amino acid mutations were found in both two isolates. • H7N9 isolations obtained in the study were differed f...

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Veröffentlicht in:	Journal of clinical virology 2015-02, Vol.63, p.18-24
Hauptverfasser:	Mao, HaiYan, Guo, Bin, Wang, FengYing, Sun, Yi, Lou, XiuYu, Chen, Yin, Zhang, Lei, Wang, XinYing, Li, Zhen, Liu, SheLan, Qin, ShuWen, Wei, JunChao, Pang, ZhiFeng, Chen, ZhiPing, Zhang, YanJun
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Avian influenza Child China - epidemiology Cluster Analysis Cytokine Cytokines - blood Environmental Microbiology Family cluster Family Health Female H7N9 Humans Infant Infectious Disease Influenza A Virus, H7N9 Subtype - classification Influenza A Virus, H7N9 Subtype - isolation & purification Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - pathology Influenza, Human - virology Male Molecular Sequence Data Phylogenetic Phylogeny RNA, Viral - genetics Sequence Analysis, DNA
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Zusammenfassung:	Highlights • We reported a family clustering case for two girls in Zhejiang Province, China. • The index patient with higher level of cytokines suffered more serious infection. • Significant amino acid mutations were found in both two isolates. • H7N9 isolations obtained in the study were differed from stains previously in Zhejiang. • Ambiguous to determining whether it was co-exposure or human-to-human transmission.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.11.034