Expansion of the dentate mossy fiber–CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus

Highlights • BDNF expression is chronically increased in the hippocampus of TgBDNF mice. • Mossy fiber volume in CA3 is enlarged by 2–3 months of age in TgBDNF mice. • At seizure-prone ages (6–7 months) mossy fiber volume increases further. • By 8 months, granule cell number is also significantly in...

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Veröffentlicht in:	Neuroscience 2015-03, Vol.288, p.10-23
Hauptverfasser:	Isgor, C, Pare, C, McDole, B, Coombs, P, Guthrie, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - growth & development CA3 Region, Hippocampal - metabolism Cell Count dentate granule cells Dentate Gyrus - growth & development Dentate Gyrus - metabolism epilepsy Female hippocampus Male Mice, Inbred C57BL Mice, Transgenic Neurology Neurons - cytology Neurons - metabolism Pilocarpine Rats RNA, Messenger - metabolism seizure Seizures - metabolism TrkB
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Zusammenfassung:	Highlights • BDNF expression is chronically increased in the hippocampus of TgBDNF mice. • Mossy fiber volume in CA3 is enlarged by 2–3 months of age in TgBDNF mice. • At seizure-prone ages (6–7 months) mossy fiber volume increases further. • By 8 months, granule cell number is also significantly increased in TgBDNF mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.12.036