Use of Sensors in a Scale-Down Simulator: Studying the Impact of Industrial-Scale Inhomogeneities on Microbial Cultures

Hamilton's VisiFerm Arc 120 dissolved oxygen and Polilyte Plus Arc 120 pH sensors are valuable tools when used in a plug flow reactor (PFR) to measure the metabolic response of Bacillus subtilis to oxygen availability. The PFR is connected to a common stirred tank reactor (STR) to simulate cond...

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Veröffentlicht in:Genetic engineering & biotechnology news 2014-03, Vol.34 (6), p.32-33
Hauptverfasser: Junne, Stefan, Klingner, Arne, Itzeck, Dirk, Neubauer, Peter
Format: Magazinearticle
Sprache:eng
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Zusammenfassung:Hamilton's VisiFerm Arc 120 dissolved oxygen and Polilyte Plus Arc 120 pH sensors are valuable tools when used in a plug flow reactor (PFR) to measure the metabolic response of Bacillus subtilis to oxygen availability. The PFR is connected to a common stirred tank reactor (STR) to simulate conditions in large-scale industrial processes. The impact of inhomogeneities of oxygen, and potentially pH, on Bacillus subtilis cultivations were observed. This study leads to the determination that such inhomogeneities will also exist, and can be measured and corrected, in industrial processes.
ISSN:1935-472X
1937-8661
DOI:10.1089/gen.34.06.15