Changes in cognition, arm function and lower body function after Slow-Release Fampridine treatment

Changes in cognition, arm function and lower body function after Slow-Release Fampridine treatment

Objective: We aimed to evaluate the effect of slow-release (SR) Fampridine on multiple outcome measures reflecting different domains, and to compare the responsiveness of the Six Spot Step Test (SSST) and the Timed 25 Foot Walk (T25FW). Methods: For this study 108 participants were included. On day...

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Veröffentlicht in:Multiple sclerosis 2014-12, Vol.20 (14), p.1872-1880
Hauptverfasser: Jensen, HB, Ravnborg, M, Mamoei, S, Dalgas, U, Stenager, E
Format: Artikel
Sprache:eng
Schlagworte:
4-Aminopyridine - therapeutic use
Adult
Arm
Cognition
Cohort Studies
Delayed-Action Preparations
Exercise Test
Female
Humans
Leg
Male
Middle Aged
Motor Skills
Multiple Sclerosis - drug therapy
Multiple Sclerosis - physiopathology
Potassium Channel Blockers - therapeutic use
Prospective Studies
Treatment Outcome
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Zusammenfassung:Objective: We aimed to evaluate the effect of slow-release (SR) Fampridine on multiple outcome measures reflecting different domains, and to compare the responsiveness of the Six Spot Step Test (SSST) and the Timed 25 Foot Walk (T25FW). Methods: For this study 108 participants were included. On day 0 they were tested with the T25FW, the SSST, the 9-Hole Peg Test (9-HPT), the 5 Times Sit-To-Stand test (5-STS) and the Symbol Digit Modalities Test (SDMT). Four weeks of treatment with SR Fampridine 10 mg BID was commenced. Participants were tested again after 26–28 days of treatment. Results: Mean changes observed were: SSST −3.4±6.4s (p
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458514533844