TGF- beta 1 signal pathway in the regulation of inflammation in patients with atrial fibrillation
Objective: To observe the expression changes of inflammatory markers TGF- beta 1, Smad3 and IL-6 in patients with atrial fibrillation (AF), and to explore the significance of TGF- beta 1 signaling pathway in the structural remodeling of AF. Methods: The expression of TGF- beta 1, Smad3 and IL-6 in 5...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2013-12, Vol.6 (12), p.999-1003 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Objective: To observe the expression changes of inflammatory markers TGF- beta 1, Smad3 and IL-6 in patients with atrial fibrillation (AF), and to explore the significance of TGF- beta 1 signaling pathway in the structural remodeling of AF. Methods: The expression of TGF- beta 1, Smad3 and IL-6 in 50 cases with AF and 30 normal cases were detected by RT-PCR and ELISA. Results: The TGF- beta 1, Smad3 and IL-6 mRNA and protein expression levels in patients with AF were significantly higher than that in the control group (P0.05). The TGF- beta 1mRNA expression in the >= 50 years subgroup was significantly higher than that in the = 36 months subgroup than that in |
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| ISSN: | 1995-7645 |
| DOI: | 10.1016/S1995-7645(13)60180-7 |