Rhizoctonia bataticola lectin (RBL) induces phenotypic and functional characteristics of macrophages in THP-1 cells and human monocytes

Highlights • RBL induced macrophage differentiation in human monocytes and THP-1 cell line. • RBL enhanced activation markers, cytokine secretion and phagocytic activity. • RBL stimulation mimics the combined effect of PMA and LPS in THP-1 cells. • RBL induces MMP-9 activity in THP-1 cells. • NF-κB...

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Veröffentlicht in:	Immunology letters 2015-02, Vol.163 (2), p.163-172
Hauptverfasser:	Pujari, Radha, Kumar, Natesh, Ballal, Suhas, Eligar, Sachin M, Anupama, S, Bhat, Ganapati, Swamy, Bale M, Inamdar, Shashikala R, Shastry, Padma
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Binding, Competitive Cell Adhesion - drug effects Cell Differentiation - drug effects Cell Line, Tumor Cells, Cultured Cytokines - metabolism Differentiation Enzyme-Linked Immunosorbent Assay Flow Cytometry Fungal lectin Humans Intercellular Adhesion Molecule-1 - metabolism Lectins - metabolism Lectins - pharmacology Lipopolysaccharides - pharmacology Macrophage Macrophage Activation - drug effects Macrophages - drug effects Macrophages - metabolism Matrix Metalloproteinase 9 - metabolism Microscopy, Confocal Monocyte Monocytes - drug effects Monocytes - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nitriles - pharmacology Phagocytosis Phagocytosis - drug effects Rhizoctonia - chemistry Rhizoctonia bataticola Sulfones - pharmacology Tetradecanoylphorbol Acetate - pharmacology
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Zusammenfassung:	Highlights • RBL induced macrophage differentiation in human monocytes and THP-1 cell line. • RBL enhanced activation markers, cytokine secretion and phagocytic activity. • RBL stimulation mimics the combined effect of PMA and LPS in THP-1 cells. • RBL induces MMP-9 activity in THP-1 cells. • NF-κB pathway plays an important role in RBL-induced differentiation.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.12.005