The Relation of Peripubertal and Pubertal Growth to Final Adult Height in Children with Classic Congenital Adrenal Hyperplasia

Objectives To determine the relationships between peripubertal and pubertal timing and growth, along with glucocorticoid exposure, to the reduced final adult height seen in patients with congenital adrenal hyperplasia (CAH). Study design Chart review of 104 children with classic CAH (41 males: 28 sa...

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Veröffentlicht in:	The Journal of pediatrics 2015-03, Vol.166 (3), p.743-750
Hauptverfasser:	Bomberg, Eric M., MD, Addo, O. Yaw, PhD, Kyllo, Jennifer, MD, Gonzalez-Bolanos, Maria T., MD, Ltief, Aida M., MD, Pittock, Siobhan, MD, Himes, John H., PhD, Miller, Bradley S., MD, PhD, Sarafoglou, Kyriakie, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Hyperplasia, Congenital - diagnosis Adrenal Hyperplasia, Congenital - drug therapy Adrenal Hyperplasia, Congenital - physiopathology Aging - physiology Body Height - drug effects Body Height - physiology Body Mass Index Child Child, Preschool Female Glucocorticoids - therapeutic use Humans Infant Infant, Newborn Male Pediatrics Prognosis Retrospective Studies Sexual Maturation - drug effects Sexual Maturation - physiology
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Zusammenfassung:	Objectives To determine the relationships between peripubertal and pubertal timing and growth, along with glucocorticoid exposure, to the reduced final adult height seen in patients with congenital adrenal hyperplasia (CAH). Study design Chart review of 104 children with classic CAH (41 males: 28 salt-wasting, 13 simple-virilizing; 63 females: 38 salt-wasting, 25 simple-virilizing) were selected from a cohort from 3 medical institutions in Minnesota. Triple logistic modeling of longitudinal data was performed to determine patterns of peripubertal and pubertal growth. Results Hydrocortisone dose was similar between subtypes and during all growth periods. Simple-virilizing boys ( P
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2014.11.027