ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes
Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.
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| Veröffentlicht in: | Journal of dermatological science 2015-05, Vol.78 (2), p.133-142 |
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| container_title | Journal of dermatological science |
| container_volume | 78 |
| creator | Kawaguchi, Masakazu Hozumi, Yutaka Suzuki, Tamio |
| description | Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently. |
| doi_str_mv | 10.1016/j.jdermsci.2015.02.020 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-ac7bead315aae9db7c8908f61647ee6a5adc863b69c35b32a74a5d769c6b7d713</citedby><cites>FETCH-LOGICAL-c517t-ac7bead315aae9db7c8908f61647ee6a5adc863b69c35b32a74a5d769c6b7d713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jdermsci.2015.02.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawaguchi, Masakazu</creatorcontrib><creatorcontrib>Hozumi, Yutaka</creatorcontrib><creatorcontrib>Suzuki, Tamio</creatorcontrib><title>ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes</title><title>Journal of dermatological science</title><addtitle>J Dermatol Sci</addtitle><description>Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.</description><subject>ADAM protease</subject><subject>ADAM Proteins - antagonists & inhibitors</subject><subject>alpha-MSH - metabolism</subject><subject>Amyloid Precursor Protein Secretases - antagonists & inhibitors</subject><subject>Amyloid Precursor Protein Secretases - genetics</subject><subject>Amyloid Precursor Protein Secretases - metabolism</subject><subject>Aspartic Acid Endopeptidases - genetics</subject><subject>Aspartic Acid Endopeptidases - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Dermatology</subject><subject>Dipeptides - pharmacology</subject><subject>gp100 Melanoma Antigen - metabolism</subject><subject>Humans</subject><subject>Interferon Type I - metabolism</subject><subject>Melanins - biosynthesis</subject><subject>Melanocyte</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - metabolism</subject><subject>Melanocytes - ultrastructure</subject><subject>Melanogenesis</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Melanoma, Experimental - ultrastructure</subject><subject>Melanosome</subject><subject>Melanosomes - drug effects</subject><subject>Melanosomes - ultrastructure</subject><subject>Microphthalmia-Associated Transcription Factor - metabolism</subject><subject>Microscopy, Electron</subject><subject>Monophenol Monooxygenase - metabolism</subject><subject>PMEL17</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Protease Inhibitors - pharmacology</subject><subject>RNA, Small Interfering - pharmacology</subject><issn>0923-1811</issn><issn>1873-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1r3DAQFaWl2ab9C8HHXrzVSJZkX0qXJP2ADQm0hd6ELM1u5NpyKtmF_feV2U0PuQQGhIb33sy8R8gF0DVQkB-6decwDsn6NaMg1pTloi_ICmrFSyGbXy_JijaMl1ADnJE3KXWUUsGq5jU5Y6KGulZsRdrN1eameIjjhCZh4cO9b_00xlREdLPFYsDehHGPAZNPRXvI_f3cm8mHfXF3c70FtbAtprR0fCju58GEE80eJkxvyaud6RO-O73n5Ofn6x-XX8vt7Zdvl5ttaQWoqTRWtWgcB2EMNq5Vtm5ovZMgK4UojTDO1pK3srFctJwZVRnhVP7KVjkF_Jy8P-rmff7MmCY9-GSxz4vgOCcNUnGqqopVGSqPUBvHlCLu9EP0g4kHDVQv_upOP_qrF381ZbloJl6cZsztgO4_7dHQDPh0BGC-9K_HqLMEBovOR7STdqN_fsbHJxK298Fb0__GA6ZunGPIPmrQKRP09yXlJWQQOWDVAP8H2ZOlvg</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Kawaguchi, Masakazu</creator><creator>Hozumi, Yutaka</creator><creator>Suzuki, Tamio</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes</title><author>Kawaguchi, Masakazu ; Hozumi, Yutaka ; Suzuki, Tamio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-ac7bead315aae9db7c8908f61647ee6a5adc863b69c35b32a74a5d769c6b7d713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ADAM protease</topic><topic>ADAM Proteins - antagonists & inhibitors</topic><topic>alpha-MSH - metabolism</topic><topic>Amyloid Precursor Protein Secretases - antagonists & inhibitors</topic><topic>Amyloid Precursor Protein Secretases - genetics</topic><topic>Amyloid Precursor Protein Secretases - metabolism</topic><topic>Aspartic Acid Endopeptidases - genetics</topic><topic>Aspartic Acid Endopeptidases - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Dermatology</topic><topic>Dipeptides - pharmacology</topic><topic>gp100 Melanoma Antigen - metabolism</topic><topic>Humans</topic><topic>Interferon Type I - metabolism</topic><topic>Melanins - biosynthesis</topic><topic>Melanocyte</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - metabolism</topic><topic>Melanocytes - ultrastructure</topic><topic>Melanogenesis</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Melanoma, Experimental - ultrastructure</topic><topic>Melanosome</topic><topic>Melanosomes - drug effects</topic><topic>Melanosomes - ultrastructure</topic><topic>Microphthalmia-Associated Transcription Factor - metabolism</topic><topic>Microscopy, Electron</topic><topic>Monophenol Monooxygenase - metabolism</topic><topic>PMEL17</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Protease Inhibitors - pharmacology</topic><topic>RNA, Small Interfering - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawaguchi, Masakazu</creatorcontrib><creatorcontrib>Hozumi, Yutaka</creatorcontrib><creatorcontrib>Suzuki, Tamio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatological science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaguchi, Masakazu</au><au>Hozumi, Yutaka</au><au>Suzuki, Tamio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes</atitle><jtitle>Journal of dermatological science</jtitle><addtitle>J Dermatol Sci</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>78</volume><issue>2</issue><spage>133</spage><epage>142</epage><pages>133-142</pages><issn>0923-1811</issn><eissn>1873-569X</eissn><abstract>Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>25818872</pmid><doi>10.1016/j.jdermsci.2015.02.020</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0923-1811 |
| ispartof | Journal of dermatological science, 2015-05, Vol.78 (2), p.133-142 |
| issn | 0923-1811 1873-569X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ADAM protease ADAM Proteins - antagonists & inhibitors alpha-MSH - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Cell Line, Tumor Dermatology Dipeptides - pharmacology gp100 Melanoma Antigen - metabolism Humans Interferon Type I - metabolism Melanins - biosynthesis Melanocyte Melanocytes - drug effects Melanocytes - metabolism Melanocytes - ultrastructure Melanogenesis Melanoma, Experimental - metabolism Melanoma, Experimental - ultrastructure Melanosome Melanosomes - drug effects Melanosomes - ultrastructure Microphthalmia-Associated Transcription Factor - metabolism Microscopy, Electron Monophenol Monooxygenase - metabolism PMEL17 Pregnancy Proteins - metabolism Protease Inhibitors - pharmacology RNA, Small Interfering - pharmacology |
| title | ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes |
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