ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes

Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2015-05, Vol.78 (2), p.133-142
Hauptverfasser:	Kawaguchi, Masakazu, Hozumi, Yutaka, Suzuki, Tamio
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM protease ADAM Proteins - antagonists & inhibitors alpha-MSH - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Cell Line, Tumor Dermatology Dipeptides - pharmacology gp100 Melanoma Antigen - metabolism Humans Interferon Type I - metabolism Melanins - biosynthesis Melanocyte Melanocytes - drug effects Melanocytes - metabolism Melanocytes - ultrastructure Melanogenesis Melanoma, Experimental - metabolism Melanoma, Experimental - ultrastructure Melanosome Melanosomes - drug effects Melanosomes - ultrastructure Microphthalmia-Associated Transcription Factor - metabolism Microscopy, Electron Monophenol Monooxygenase - metabolism PMEL17 Pregnancy Proteins - metabolism Protease Inhibitors - pharmacology RNA, Small Interfering - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Melanin content was reduced by the treatment with ADAM protease inhibitor. • The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor. • ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2015.02.020