Combination drug release of smart cyclodextrin-gated mesoporous silica nanovehicles

An integrated γ-cyclodextrin-gated mesoporous silica delivery system via dual dynamic covalent bonds was constructed with dual drug loading for simultaneous and cascade release in targeted combination drug therapy.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (33), p.7203-7206
Hauptverfasser:	Zhou, Shengwang, Sha, Huizi, Ke, Xiaokang, Liu, Baorui, Wang, Xizhang, Du, Xuezhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Drug Carriers - chemistry Drug Carriers - metabolism Drug Liberation gamma-Cyclodextrins - chemistry HeLa Cells Humans Nanoparticles - chemistry Porosity Silicon Dioxide - chemistry
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Beschreibung
Zusammenfassung:	An integrated γ-cyclodextrin-gated mesoporous silica delivery system via dual dynamic covalent bonds was constructed with dual drug loading for simultaneous and cascade release in targeted combination drug therapy.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc00585j