Further Evidence of Harm From Exercise in ARVD/C

Aerobic exercise has remarkable cardiovascular benefits, decreasing the risk of atherosclerosis, reducing death from heart failure, lowering blood pressure, decreasing abdominal fat, lowering glycosylated hemoglobin in diabetes mellitus, and improving sarcopenia (15-18); however, endurance athletics...

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Veröffentlicht in:	Journal of the American College of Cardiology 2015-04, Vol.65 (14), p.1451-1453
Hauptverfasser:	Judge, Daniel P., MD, Chelko, Stephen P., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arrhythmia Arrhythmogenic Right Ventricular Dysplasia - genetics Cardiology Cardiomyopathy Cardiovascular exercise Humans Internal Medicine Mutation Mutation - genetics Pathogenesis Phenotype Physical Conditioning, Animal - physiology Plakophilins - genetics Proteins Rodents sudden cardiac death
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Zusammenfassung:	Aerobic exercise has remarkable cardiovascular benefits, decreasing the risk of atherosclerosis, reducing death from heart failure, lowering blood pressure, decreasing abdominal fat, lowering glycosylated hemoglobin in diabetes mellitus, and improving sarcopenia (15-18); however, endurance athletics is not without some risk. Peroxisome proliferator-activated receptor (PPAR)-Î³ and PPAR-[alpha] stimulation of induced pluripotent stem cell-derived cardiomyocytes from patients with ARVD/C leads to exaggerated lipogenesis and apoptosis, which implicates this pathway in ARVD/C pathogenesis (22). Because exercise upregulates the PPAR-Î³ pathway, this may contribute to the harmful effects of exercise for patients with ARVD/C (23).
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2015.01.046