Increased Risk for and Mortality From Invasive Pneumococcal Disease in HIV-Exposed but Uninfected Infants Aged <1 Year in South Africa, 2009–2013

Increased Risk for and Mortality From Invasive Pneumococcal Disease in HIV-Exposed but Uninfected Infants Aged <1 Year in South Africa, 2009–2013

Background. High antenatal human immunodeficiency virus (HIV) seroprevalence rates (∼30%) with low perinatal HIV transmission rates (2.5%), due to HIV prevention of mother-to-child transmission program improvements in South Africa, has resulted in increasing numbers of HIV-exposed but uninfected (HE...

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Veröffentlicht in:Clinical infectious diseases 2015-05, Vol.60 (9), p.1346-1356
Hauptverfasser: von Mollendorf, Claire, von Gottberg, Anne, Tempia, Stefano, Meiring, Susan, de Gouveia, Linda, Quan, Vanessa, Lengana, Sarona, Avenant, Theunis, du Plessis, Nicolette, Eley, Brian, Finlayson, Heather, Reubenson, Gary, Moshe, Mamokgethi, O'Brien, Katherine L., Klugman, Keith P., Whitney, Cynthia G., Cohen, Cheryl
Format: Artikel
Sprache:eng
Schlagworte:
ARTICLES AND COMMENTARIES
Cross-Sectional Studies
Epidemiology
Female
Health risk assessment
HIV
HIV Infections - diagnosis
HIV Infections - microbiology
Human immunodeficiency virus
Humans
Immunization
Incidence
Infant
Infant, Newborn
Male
Mortality
Pediatrics
Pneumococcal Infections - complications
Pneumococcal Infections - epidemiology
Pneumococcal Infections - mortality
Pneumococcal Infections - virology
Pneumococcal Vaccines - administration & dosage
Regression Analysis
Risk Factors
Seroepidemiologic Studies
South Africa - epidemiology
Streptococcus infections
Time Factors
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Zusammenfassung:Background. High antenatal human immunodeficiency virus (HIV) seroprevalence rates (∼30%) with low perinatal HIV transmission rates (2.5%), due to HIV prevention of mother-to-child transmission program improvements in South Africa, has resulted in increasing numbers of HIV-exposed but uninfected (HEU) children. We aimed to describe the epidemiology of invasive pneumococcal disease (IPD) in HEU infants. Methods. We conducted a cross-sectional study of infants aged
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/civ059