Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy

Highlights • Advanced gallbladder cancer has poor prognosis and inherent resistance to adjuvant therapy. • The genetic and epigenetic alterations play an important role in gallbladder carcinogenesis. • Emergent signaling pathways in GBC must be explored in order to design rational therapies. • The u...

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Veröffentlicht in:	Cancer treatment reviews 2015-03, Vol.41 (3), p.222-234
Hauptverfasser:	Bizama, Carolina, García, Patricia, Espinoza, Jaime A, Weber, Helga, Leal, Pamela, Nervi, Bruno, Roa, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Directing rational cancer therapy Gallbladder cancer Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - genetics Gallbladder Neoplasms - metabolism Genetic and epigenetic alterations Hematology, Oncology and Palliative Medicine Humans Intracellular pathways Molecular Targeted Therapy Signal Transduction - drug effects
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Zusammenfassung:	Highlights • Advanced gallbladder cancer has poor prognosis and inherent resistance to adjuvant therapy. • The genetic and epigenetic alterations play an important role in gallbladder carcinogenesis. • Emergent signaling pathways in GBC must be explored in order to design rational therapies. • The use the inhibitors of oncogenic pathways is a promising therapeutic alternative in GBC.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.01.003